A gene in the brain that was not previously linked to mood disorders could have a role in biopolar, depression, and schizophrenic conditions.
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Posts tagged as:
Gene
A study appearing in Science Translational Medicine puts scientists one step closer to clinical trials to test a gene delivery strategy to improve muscle mass and function in patients with certain degenerative muscle disorders.
Severe weakness of the quadriceps is a defining feature of several neuromuscular disorders. Researchers at Nationwide Children`s Hospital have shown that a [...]
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A new study reveals that a previously undiscovered mouse gene reduces the two major pathological perturbations commonly associated with Alzheimer`s disease (AD). The research, published in the November 12 issue of the journal Neuron, finds that the novel gene interacts with a key cellular enzyme previously linked with AD pathology, thereby uncovering a new strategy [...]
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If humans are genetically related to chimps, why did our brains develop the innate ability for language and speech while theirs did not?
Scientists suspect that part of the answer to the mystery lies in a gene called FOXP2. When mutated, FOXP2 can disrupt speech and language in humans. Now, a UCLA/Emory study reveals major differences [...]
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Embryonic development is like a well-organised building project, with the embryo`s DNA serving as the blueprint from which all construction details are derived. Cells carry out different functions according to a developmental plan, by expressing, i.e. turning on, different combinations of genes. These patterns of gene expression are controlled by transcription factors: molecules which bind [...]
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Researchers at the California Institute of Technology (Caltech) have shown that a highly specific intrabody (an antibody fragment that works against a target inside a cell) is capable of stalling the development of Huntington`s disease in a variety of mouse models.
"Gene therapy in these models successfully attenuated the symptoms of Huntington`s disease and increased life [...]
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The metastasis or spread of breast cancer to other tissues in the body can be predicted more accurately by examining subnetworks of gene expression patterns in a patient`s tumor, than by conventional gene expression microarrays, according to a presentation at the American Society for Cell Biology (ASCB) 48th Annual Meeting, Dec. 13-17, 2008 in San [...]
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Reducing the activity of a gene called FKBP12 in the brains of mice affected neuron-to-neuron communication (synapse) and increased both fearful memory and obsessive behavior, indicating the gene could provide a target for drugs to treat diseases such as autism spectrum disorder, obsessive-compulsive disease and others, said researchers from Baylor College of Medicine in Houston [...]
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Scientists have found that genetic variation at the hexokinase-1 gene is linked to variation in the blood concentration of glycated hemoglobin, an index of long-term blood glucose concentration widely used in the follow-up of diabetes patients. The study was conducted by researchers from the Brigham and Women`s Hospital in Boston, USA.
Diabetes is a leading [...]
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Researchers at the University of Rochester have designed a gene that produces a thousand times more protein in cancer cells than in healthy cells.
The findings may help address the prime challenge in anti-cancer therapy: improving treatments` ability to specifically and effectively target cancer cells. Using this new approach, scientists should be able to insert "self-destruct" [...]
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